Redshift 3 and Vista after installation - will only run from CD

Windows Vista is turning my hair into grey.
The new pc with Vista, now demands that a LOT of the old programs
neeeds the CD in the -drive ongoing to be executed,
even though they were meant to be installed and executed from the hardrive
only,
once installated.
For instance Redshift 3, which refuses to run without the CD.
(Works fine on our old XP machine)
Copying all the files to the HDD on the new PC and executing from there
doesn´t help.

Any suggestions ?

PS. Keep your XP operating system.
Vista is.....(censored)

Pete