The SLS is the next giant rocket that will be used for long range manned spaceflight, or the moon as a target. But it's way over budget (how much is really left for it after the ISS sucks up so much?). Some of the technology being used to built it is different. Like friction welding to put the tanks (outboard, like the Shuttle) together in sections.

https://www.nasa.gov/exploration/systems/sls/index.html