None of the above.

A launcher in the 25,000kg payload to LEO and then design
around Earth Orbit Rendevous.

Or how about standing up 4 of these launchers side by side on the launch pad
and lash them together so they can lift a 100 tone payload to orbit?

Earth orbit rendevous means lingering in orbit for a while exposed to space
junk while your waiting to get the other pieces up. You have to put pieces A,
B, C, and D together. What if there is something wrong with piece B, that only
becomes apparent once it reaches orbit? A, C, and D are just fine, so they wait
in orbit, getting exposed to more space junk while a replacement for be is
assembled and another launcher is built to launch it. The comes the process of
assembly. Send the astroworkers into orbit, these people aren't going to the
moon, their task is to assemble the moonship. They better have brought all the
tools their going to need. The process needs to be carefully choriographed in
swimming pools with mockups. The Lunar geologists await on Earth while the
mission of assemble goes on. The mission in this case begins with assembly
rather than a launch.

Tom