P. Edward Murray wrote:
There have to be some fixed laws. If not then how does anything work?
The whole basis for science is that the Universe is understandable.



That is their point -- the laws and constants we observe now may not
have applied in the past and will likely change in the future. The Grand
Scheme of science which explains all may only be an illusion. That's not
to say we haven't done useful work or made valid discoveries (the
periodic table, bottled draft beer, mathematics, etc.), but the ultimate
goal in physics of a theory which unifies observed forces and explains
their origin may not be knowable.